Kotoko to open title defence against new boys Amidaus
Asante Kotoko won the Ghana Premier League last season
Kotoko's rivals Hearts of Oak will visit Tema Youth for their opener, while last season's runners-up AshantiGold travel to promoted Real Tamale United.
Returnees King Faisal will play their first match at Liberty Professionals.
Dethroned champions Berekum Chelsea face Heart of Lions at the Golden City Park.
Ebusua Dwarfs continue their home match ban by hosting Berekum Arsenals at the Len Clay Stadium in Obuasi.
The first Ghana Premier League derby between Asante Kotoko and Hearts of Oak will be at Baba Yara Stadium in Kumasi on November 18.
The league goes on a break on January 13 after the week 15 fixtures to halve the season.