Debutants Chelsea eye Zamalek scalp
Berekum Chelsea are aiming to beat Zamalek
But the Blues will have to do that at the adopted Accra Sports Stadium after their favoured Golden City Park in Berekum was failed to meet CAF's requirements.
The dethroned Ghana Premier League champions proved their worth by eliminating Raja Casablanca and 2008 runners-up Coton Sport Garoua.
The club received a boost on Wednesday when trio captain Abdul Basit, Solomon Asante and Richard Kissi Boateng trained with the squad.
But right-back Eric Agyemang is suspended for the tie after picking yellow cards in penultimate and final qualifying rounds.
Zamalek have had their problems in recent times after legendary coach Hassan Shehata stepped down but the club's board rejected his resignation.
Star midfielder Shikabala is also out after falling out with Shehata by the end of last season.
The five-time champions lack the match fitness after playing only one match against MAS Fes in the qualifying round.
Egypt captain Ahmed Hassan, striker Razak Omotoyossi and Egypt Olympic team defender Salah Soliman will be missed due to suspension.
Zamalek last won the CAF Champions League in 2002.