Mazembe take aim at Chelsea
TP Maembe Team Picture
The Ravens will still remain at the summit on the head-to-head rule if their closest challengers Al Ahly also win against Zamalek as the group's final matches are played.
Mazembe and Ahly have 10 points going into the final round of matches and if the Congolese can match the Egyptians' result, they will win the mini-league on the head-to-head rule.
The four-time champions have been boosted by the return of the ten internationals who played for DR Congo and Zambia in the 2013 Nations Cup qualifiers at the weekend.
Coach Lamine N'Diaye watched his side throw away a 2-0 lead to draw 2-2 against the Ghanaian side who are out of contention for the semi-final ticket.
Mazembe however improved on their mistakes and have won their last three encounters in this year's competition.
Berekum Chelsea, who were making their debut, want to sign off their campaign on a winning note and hurt Mazembe who want to avoid facing holders Esperance in the semis.
"We know we are out of the competition but we want to prove a point that we are capable. We will not relent," Chelsea spokesman Joe Addo said.
"We want to finish on a good note and we want to badly beat Mazembe on our home soil."
The Blues are likely to be without lead striker Emmanuel Clottey who has signed a three-year deal for Esperance but will be eligible for the Tunis-based side in December.
Right-back Eric Agyemang is available for selection but centre back Awudu Nafiu is suspended for the tie after picking up two yellow cards.
The match will be played at the Accra Sports Stadium at 15: 00 GMT.